Abstract
Many drugs have been implicated as causative factors of adverse cutaneous reactions. The histologic picture of these eruptions, most often, is nonspecific—bullous eczema, erythema nodosum, perivasculitis, vasculitis, for example. Some reactions, however, result in more specific histologic patterns, as in lichenoid eruptions, erythema multiforme, bullous pemphigoid, and arsenical keratoses. Clinicians, therefore, may or may not receive significant diagnostic help from biopsy procedures. Nonetheless, in difficult diagnostic situations, histopathologic examination of the skin lesions should be carried out. In this chapter, a description is given of cutaneous reaction patterns commonly encountered in adverse drug reactions.
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