Abstract
BACKGROUND: Extrathyroidal tumor extension is a poor prognostic marker in papillary thyroid carcinoma. Recent reports have shown that a histologic grading (based on nuclear atypia, tumor necrosis, and vascular invasion) is a strong prognostic marker for outcome. In this report we used the classification based on histological grading in patients with locally invasive papillary carcinoma. METHODS: Forty consecutive patients with locally invasive primary papillary thyroid carcinoma were studied. Twenty-four patients had radioiodine treatment and all patients received thyroxin treatment postoperatively. Tumor specimens were reviewed retrospectively and classified as grade I or grade II according to the presence of nuclear atypia, tumor necrosis, or vascular invasion. RESULTS: 23 patients were classified as grade I and 17 as grade II. No difference in overall survival was seen between the two groups. CONCLUSIONS: Histological grading based on a combined examination of nuclear atypia, tumor necrosis, and vascular invasion did not show any influence on survival in 40 patients with locally invasive PTC.
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