Abstract
Background Extracellular matrix expansion is fundamental to left ventricular (LV) remodeling, and is a therapeutic target. CMR techniques are increasingly used to evaluate myocardial extracellular volume (ECV), however the most widely applied methods are without histological validation. The aim of this study was to provide whole-heart, histological validation of; 1. Dynamic-equilibrium CMR (DynEq-CMR), where ECV is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and 2. Isolated measurement of myocardial T1 at a fixed time-point following gadolinium bolus, used as an ECV surrogate.
Highlights
Extracellular matrix expansion is fundamental to left ventricular (LV) remodeling, and is a therapeutic target
DynEq-CMR-derived extracellular volume (ECV) was linearly related to histological CVF (p
Correlation was maintained throughout the entire heart, and when segments displaying late gadolinium enhancement (LGE) were included and excluded
Summary
Extracellular matrix expansion is fundamental to left ventricular (LV) remodeling, and is a therapeutic target. CMR techniques are increasingly used to evaluate myocardial extracellular volume (ECV), the most widely applied methods are without histological validation. The aim of this study was to provide whole-heart, histological validation of; 1. Dynamic-equilibrium CMR (DynEq-CMR), where ECV is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and 2. Isolated measurement of myocardial T1 at a fixed time-point following gadolinium bolus, used as an ECV surrogate
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