Abstract
The evolution of tissue reaction around the subcutaneous injection of 20-methylcholanthrene diluted in trioctanin has been studied in the rat from the stage immediately following inoculation to the onset of sarcoma. Such reaction has been compared with the reaction observed around the inoculation of pure solvent. The tissue reaction around the oncogenic substance consists of: An early appearance of cellular foci at a certain distance from the oncogenic solution; these are made of various elements, among which a gradually increasing number of cells of the immature fibroblast type; The formation, around both the oncogenic solution and cellular foci, of a connective tissue with scanty cells which is characterized by an amorphous extracellular component or is irregularly organized in fibres with morphological and histochemical properties far different from those observed in the reaction of tissue around pure solvent. A relationship has been established between this newly - formed connective tissue and the dermal alterations observed by the same authors in the course of epithelial skin cancerogenesis.
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