Histological study of the effect of Piroxicam on testes of albino mice Mus musculus

Abstract

Non- Steroidal Anti Inflammatory Drugs (NSAIDs) are the most frequently prescribed therapeutic agents, used for the treatment of rheumatic diseases, because they have analgesic, antipyretic and anti inflammatory action. Piroxicam is a well-known member of family NSAIDs use to reduce inflammation, pain associated with arthritis , osteoarthritis and ankylosing spondylitis .The objective of the present study is to evaluate the effect of different doses of Piroxicam upon testis tissue in mice. Twenty four male albino Swiss mice were randomly divided into control (n = 6 ) and experimental (n =18) groups .The experimental groups are subdivides into three groups of six mice. Each received (0.29, 1.428, 2.857)mg/kg/day for fourteenth days , respectively ; however the control group just received distill water. In fifteenth day , mice were killed and testes tissue was prepared for light microscopic study .All animals exposed to drug were serve to have a depletion of germ cells, germinal cell necrorosis , especially in Spermatogonia and Leydig cells which had an abnormal fibroblast like appearance , abnormal space between neighboring Sertoli cells, thickness in seminiferous tubules basement membrane and wall arteries, therefore it is recommended that usage of this drug have harmful side effects on male fertility.