Abstract
Aims: The aim of the present study is to investigate if short term therapy with diclofenac sodium of interferes with the time course of alveolar wound healing in rabbits. Materials and Methods: The sample included twelve rabbits; 6 rabbits received interamuscular injections of diclofenac sodium (10 mg/kg/day), one day before extraction, at a day of extraction and 4 days after extraction of the right mandibular incisors and 6 rabbits received interamuscular injections of normal saline. The animals were sacrificed in each group at 7, 14 and 21 days after tooth extraction. Results: The present results showed that the effect of diclofenac treatment caused no signifcant decrease in bone formation of socket healing. Conclusion: Histological study of short term therapy with diclofenac sodium after tooth extraction caused non-significant decrease in bone formation of extraction sockets healing in rabbits.
Highlights
Mandible anatomy: The mandible, "jawbone" forms the lower jaw and holds the lower teeth in place
At the end of the first week: Control group (C1): The alveolus of control animals was filled with many dilated blood vessels and granulation tissue which contain blood vessels, fibroblasts, and chronic inflammatory cells with predominate osteoblastic activity and newly formed trabecular bone was observed mainly on the internal surfaces of the alveolar socket and remnant of the blood clot observed in the apical third (Figures 1A and 3)
There is evidence that NSAID induced inhibition is proportional to the duration of treatment, and that bone can heal normally once NSAID administration is discontinued. (13-16) While NSAID negatively affect bone healing as indomethacin.(16,17) There is insufficient evidence to support with holding NSAID after tooth extraction
Summary
Mandible anatomy: The mandible, "jawbone" forms the lower jaw and holds the lower teeth in place. The incisive nerve runs forward in the mandible and supplies the anterior teeth.(1) Alveolar Process: is that bone of the jaws containing the sockets(alveoli) for the teeth. It consists of an outer(buccal and lingual) cortical bone, a central spongiosa, and bone lining the alveolus(alveolar bone).(2) Bone Anatomy and Histology: Bone is a dynamic biological tissue compose of metabolically active cells that are integrated into a rigid framework. The cellular components of bone consist of osteogenic precursor cells, osteoblasts, osteoclasts, osteocytes, and the hematopoietic elements of bone marrow. Osteoblasts are mature, metabolically active, bone forming cells. Osteocytes are mature osteoblasts trapped within the bone matrix. Osteons consists of cylindrical shaped lamellar bone that surrounds longitudinally oriented vascular channels called haversian canals. (3,4)
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