Histological studies on the ontogeny of bovine gut-associated lymphoid tissue: appearance of T cells and development of IgG + and IgA + cells in lymphoid follicles

Abstract

The development and distribution of lymphocyte subsets in bovine gut-associated lymphoid tissues (ileal and jejunal Peyer's patches (PP)) were examined. Before birth, the composition of lymphocyte subsets in both PP follicles did not differ except for the dimensions of the interfollicular area and the dome region. Many IgM + cells were observed in these follicles, but very few CD3 +, IgG +, and IgA + cells could be found. At neonatal period, the IgG + cells, which did not produce IgG mRNA, were dominant within both PP follicles. From 1 month after birth, many CD3 + cells, IgG mRNA expression, and IgA mRNA expression were detected within the jejunal PP follicles, but very few were in the ileal PP follicles. These data suggest that the characteristics of the jejunal PP follicles metamorphose into secondary lymphoid tissue such as germinal centers at around 1 month after birth, whereas the characteristics of ileal PP follicles were distinct from those of germinal centers.