Abstract
The effect of monosodium glutamate, used as food additive on the Kidneys of adult wistar rat was investigated. Both adult male and female Wistar rats (n=24) average weight of 185g were randomly assigned into two treatments (n=12) and control (n=6) groups. The rats in the treatment groups received 3g and 6g of Monosodium glutamate thoroughly mixed with the grower's mash daily for fourteen days. The control rats received equal amount of the grower's mash without Monosodium glutamate added daily. The grower's mash was obtained from Edo Feeds and Flour Mill Ltd, Ewu, Edo State and the rats were given water liberally. The rats were sacrificed on day fifteen of the experiment. The Kidneys were carefully dissected out and quickly fixed in 10% formal saline for histological procedures. Histological changes observed in the treated kidney sections included the distortion of the renal cortical structures and some degree of cellular necrosis. Our results suggested that the functions of the kidney could have been adversely affected due to the distortion of the cyto-architecture of the renal cortical structures and cellular necrosis associated with the kidney. It is recommended that further studies aimed at corroborating these observations be carried out.
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