Histological Spectrum of Prostatic Adenocarcinomas in Correlation with PSA Values

Abstract

Background & objectives: Histopathology is the gold standard in the diagnosis and management of prostatic adeno carcinomas. The objectives of this study are 1) To determine the age distribution and clinical presentation of patients with prostatic adenocarcinomas 2) To study various Gleason’s microscopic patterns of prostatic adenocarcinomas 3) To assign them with Gleason’s score 4) To correlate Gleason’s score with prostatic specific antigen values in these cases. Methods: The study was done on 370 prostatic specimens over a period of 4 years from June 2011 to June 2015 which included both transurethral resection of prostate chips and needle core biopsies received in the department of Pathology, NRI Medical College, Chinakakani. The study included only prostatic adenocarcinomas which constituted to 75 cases out of 370 cases, with the incidence of 20.3%. Results: Prostatic adeno carcinomas were common in the age group of 70-79 years with the three common symptoms of dysuria, incomplete voiding and frequency .The most common primary microscopic pattern was Gleason’s pattern 3, followed by pattern 4. The most common Gleason’s score was 7 (43%) which showed PSA values in the range of 21-50 ng/ml. The p value for serum PSA levels and Gleason score was 0.00001. Interpretation & Conclusions: The present study showed a strong correlation between Gleason’s score and PSA values. It is concluded that as the Gleason’s score increases the serum PSA values also increases. Key words: Adenocarcinoma of prostate; Gleason`s score; Prostate specific antigen; Trans urethral resection of prostate.