Abstract

Vagus nerve stimulation treatment (VNS) is used for multiple conditions. Among these conditions for instance are epilepsy, depression and rheumatoid arthritis. The exact mechanisms of VNS however remain elusive. This study aims to contribute to a possible explanation for VNS principle. Central as well as peripheral effects are discussed to contribute to VNS. Peripheral effects appear to rely on an intact catecholamine containing splenic nerve. Among the central connections of the vagus nerve are catecholamine containing cell groups.

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