Histological, Histochemical and Immunohistochemical Alterations Induced in Rat’s fetalskeletal Muscle Fibres and Skin Intoxicated Maternally with

Abstract

Background: skeletal muscle relaxants contain a diverse mix of agents with different buildings and tools for achievement. These agents are classified as antispasmodics or antispasmodic agents, one of them is the drug carisoprodol.Objective: the current study aimed to investigate the possible effect of somadril compound on the skeletal muscle fibres and skin of fetuses maternally treated with carisoprodol.Material and methods: 30 pregnant female rats were categorized into 3 groups equal in number ten for each group, the first one (Control group ) ten pregnant female rats were administrated oral doses of distilled water; rats of the second group (S1) were administrated oral doses of carisoprodol in distilled water equivalent to 10.8 mg / 100 g body weight/ day and rats of the third group (S2) were administrated oral dose of carisoprodol in the distilled water equivalent to 21.6 mg /100g body weight/day. Rats of S1 and S2 were administrated oral dose of carisoprodol for 15 days from the 6th day to the 20th day of gestation. Many histological, histochemical and immunohistochemical studied were done to detect the alterations in the fetal skeletal muscles and skin. Results: fetal skin and skeletal muscle tissues of both treated groups showed many changes compared to the control group. Conclusion: treatment of the pregnant rats with carisoprodol led to numerous pathological changes in the fetal skin and skeletal muscle fibres.