Histological Evaluation of the Effect of Clopidogrel (Plavix) on the Brain, Liver, and Kidney: Histopathology Study

Abstract

Clopidogrel is a prodrug that is absorbed in the intestines and 85% of it is metabolized in the liver, while 15% is the active part of the drug as it works to inhibit platelet aggregation and thus not forming a blood clot. The current study aims to evaluate the histological effect of Clopidogrel on the tissues of the, brain, liver and kidney. Experiment design: The experiment included fifteen albino rats divided randomly into three groups and each group included five animals . The first group was considered the control group. It was received tap water and natural food. As for the second group, the animals were received 15 mg/kg of Clopidogrel once a day with water and food, while the animals of the third group were received 20 mg/kg of Clopidogrel once a day with water and food. The experiment lasted for a month. After the end of the experiment, the animals were anesthetized, and the organs were surgically obtained, and the organs were placed in a 10% formalin solution, and then the tissue preparation techniques were applied to them. Results: The results of the study showed that a drug had several effects in tissues, including atrophy, caseous necrosis, apoptosis of some cells, foamaus appearance, inflammation, and degradation of other cells.