Histological evaluation of gingival enlargement response to oral folic acid administration in rabbit

Abstract

Aims of the study: to clarify the clinical and histological evaluation of oral folic acid effect on reduction of gingival enlargement. Materials and methods: The study was carried out in the collage of dentistry /university of Mosul on twelve white newzeland male rabbit with gingival enlargement weight between (900 g±1.250g). six rabbit considered as control group and the other six rabbit considered as treated group which taking 15 mg orally folic acid once daily for about 14 days then depth of gingival sulcus evaluated clinically by periodontal` probe and euthaniused for histological examination. Result: Clinically: after 14 days of drug administration, there is a high clinical differences between two group (mean +- SD), control group have (3-5mm) of gingival enlargement and experimental group have (1-3 mm) of gingival enlargement. Histological finding show significant differences in the form of gingival sulcus depth and inflammatory cell infiltration and connective tissue in control group and experimental group. Conclusion: the effect of oral administration of folic acid have higher evaluation on reducing the gingival enlargement in rabbit