Abstract
Introduction: Exposure to smokeless tobacco products (Nicotine) is associatedwith the generation of reactive oxygen species, modulation of inflammatory mediators, inhibition of collagen synthesis and impairment of DNA repair capacity whichin some way may cause harmful effects on the ovaries of the offspring.Objectives: To observe the effects of chewing tobacco on the gross morphologicaland histological alterations on the ovaries of offspring’s rats.Methodology: Twenty pregnant rats were divided in two groups: Group. A(Control) 10 pregnant rats received normal diet and water ad libitum. Group. B(Experimental) 10 pregnant rats received 5% tobacco mixed with normal feed andwater ad libitum. After 21 days, the female offspring of both control and experimental groups were sacrificed, ovaries removed and stained with H&E stains formicroscopic examination.Results: The results clearly showed that smokeless tobacco consumption duringgestation reduces the weight and size of ovary along with the congested blood vessels, compact stroma and degenerative primordial follicles. Hence the practice ofchewing tobacco in mothers is directly related to the adverse effects in offspringhealth and ovaries.
 Key words: Chewing Tobacco, Offspring, Ovaries, Rats.
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