Abstract
Impatiens balsamina Linn. is an ornamental plant with a wide range of bioactivities. This histological assessment was done as a continuation of a study that showed the anti-tumor promoting activity of its flower crude ethanol extract and isolate 2-methoxy-1,4-naphthoquinone (MeONQ) using the modified 2-stage mouse skin carcinogenicity assay. This evaluates any positive protective histological effects of the crude extract and isolate on the pancreas, stomach, duodenum and spleen of the same mice exposed to the tumor inducer dimethylbenzanthracene (DMBA) and promoter croton oil for 20 weeks. Standard paraffin technique of slide preparation was done and histological abnormalities were subjected to statistical analysis. ANOVA showed a significant difference between treatments A (DMBA and croton oil), B (DMBA and croton oil in acetone) and treatments C (DMBA, croton oil and crude extract), D (DMBA, croton oil and isolate). Treatment D showed no significant difference from the untreated. These results show that I. balsamina crude leaf extract and isolate MeONQ exhibit histoprotective effects on the pancreas, stomach, duodenum, and spleen of tumor-induced mice indicative of anti-tumor activity. Key words: Impatiens balsamina crude extract, 2-methoxy-1,4-naphthoquinone (MeONQ), mouse pancreas, stomach, duodenum, spleen.
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