Histological effect of infectious bursal disease virus on bursa of fabricia, Thymus gland and bone marrow tissues with monitoring of virus antibodies level during experimental infection on broiler chicken.

Abstract

Infectious bursal disease virus infect wide range of poultry flocks across the word causing variable ranges of economic loses come from direct or indirect mortality through immune suppression by invading of B cell tissues, this study designed to show the effect of oral and ocular inoculated virus collected and processed from infected farms on bursa of fabricia, Thymus gland, bone marrow tissues with monitoring of virus antibody titer before and after age of inoculation (21 day old), the study showed different degrees of damage varies between tissues including degeneration, necrosis, congestion and edema, the study also showed that the maternal antibodies was high at the first day of hatching and the decrement of antibody titer happen directly after virus inoculation then increase in antibodies titer started gradually after two weeks of inoculation.