Abstract
Aim. Identifi cation of possible histological differences of the Quilty effect in acute rejection and its absence as well as studying the proliferation of blood and lymph vessels in the area of Quilty damage.Materials and methods. 883 endomyocardial biopsy materials from 352 patients were studied. Histological sections were stained with hematoxylin and eosin, Masson method; the endothelium of lymphatic vessels was stained with immunoperoxidase method using a marker D2-40.Results. The Quilty effect was observed both in acute rejection and inits absence. In the majority of cases the Quilty effect was of type «A» and it was combined with acute rejection. The Quilty effect of type «B» has been mostly in the G2R. Acute rejection is characterized by diffuse form of endocardium lymphoid infi ltration. Follicular form resembles lymphoid organ tissue. Different types and forms of the Quilty effect may be combined in the same biopsy. Proliferation of blood vessels presents in the area of the Quilty effect. Lymphatic vessels are missing in endocardium and in the area of the Quilty effect. They could be found only in the myocardium of endomiocardial biopsy.Conclusion. Diffuse lymphoid infi ltration of the endocardium is a characteristic feature of acute rejection of the transplanted heart. Follicular form of the Quilty effect is similar to lymphoid tissue whose role requires further study using immunohistochemical methods.
Highlights
Acute rejection is characterized by diffuse form of endocardium lymphoid infiltration
Different types and forms of the Quilty effect may be combined in the same biopsy
Lymphatic vessels are missing in endocardium and in the area of the Quilty effect
Summary
Выявление возможных гистологических различий эффекта Quilty при остром отторжении и его отсутствии, а также изучение пролиферации кровеносных и лимфатических сосудов в зоне Quilty повреждения. Исследован материал 883 эндомиокардиальных биопсий от 352 пациентов. Эффект Quilty встречался как при остром отторжении, так и при его отсутствии. В большинстве наблюдений был эффект Quilty типа «А», и он сочетался с острым отторжением. Эффект Quilty типа «В» был преимущественно при G2R. Для острого отторжения характерна диффузная форма лимфоидной инфильтрации эндокарда. В одном и том же биоптате могут присутствовать различные типы и форма эффекта Quilty. В зоне эффекта Quilty – пролиферация кровеносных сосудов. Они находятся только в миокарде эндомиокардиальных биоптатов. Фолликулярная форма эффекта Quilty сходна с лимфоидной тканью, роль которой требует дальнейшего изучения с использованием иммуногистохимических методов исследования. Ключевые слова: эффект Quilty, эндомиокардиальная биопсия, трансплантированное сердце
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Russian Journal of Transplantology and Artificial Organs
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
