Abstract
<p class="abstrak2">Histological changes of liver in does with pregnancy ketosis were characterized. Twenty pregnant does at day 80 of pregnancy were used for this experiment. A total of 10 does were fed by grass (Napier) and goat concentrate with water ad libitum. Those 10 goats considered as healthy pregnant goat, and another 10 goats showing clinical and subclinical signs of ketosis considered as unhealthy pregnant does. Liver biopsies were performed when clinical signs appeared. Beta-Hydroxybutyrate (BHBA), free fatty acid (FFA), and glucose were dosed. Histological preparation revealed similar incidence and intensity of mild liver steatosis with lower cellular vacuolation in hepatocyte presence in healthy late pregnant does. Almost all of the pregnant does with ketosis state (n=8/10) had large amount of small lipid droplets in almost every hepatocyte over the whole liver acinus with higher number of cellular vacuolation, and related with higher BHBA and FFA levels while low in glucose level.</p>
Highlights
There was a sharp increase in goat milk and meat demand in Malaysia, in the last three decades due to rapid economic and population growth, with the resultant effects of urbanization, income growth and change of consumer preference (Bisant 2010)
This study was inline with Rook (2000) who reported that healthy pregnant showed a largely unchanged during the experiment and mild steatotic changes recorded in those does seemed to be a normal feature during late pregnancy
This study indicated that the goat with subclinical pregnancy ketosis, as determined by ketonemia, were more likely to have hypoglycaemia and azotemia compared to non ketotic pregnant goats during the third trimester pregnancy
Summary
There was a sharp increase in goat milk and meat demand in Malaysia, in the last three decades due to rapid economic and population growth, with the resultant effects of urbanization, income growth and change of consumer preference (Bisant 2010). Pregnancy ketosis has been recognized as one of the common metabolic diseases influencing goat meat and milk production (Bani-Ismail et al 2009). Pregnancy ketosis commonly occured in goat or sheep during the late stage of gestation with a low morbidity rate (2-5%) but a high mortality rate (80%) (Brounts et al 2004; Zamir et al 2009; Brozos et al 2011). The main cause of pregnancy ketosis in goats was a disturbance of carbohydrate metabolism due to high demand for glucose by the developing fetuses in the last trismester of pregnancy, resulting negative energy balance
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