Histological Changes in Proximal and Distal Convoluted Tubules of Kidney of Albino Rats after Exposure to Mosquito Coil Smoke Inhalation

Abstract

Objective: To evaluate the effects of the mosquito coil smoke (MCS) inhalation on histology of proximal (PCT) and distal (DCT) convoluted tubules of kidney in Wistar Albino rats. Methods: This study was approved by the Ethical Committee of PGMI, Lahore. 24 Wistar rats were selected and randomly divided into 3 groups, each containing eight animals. Group A was control; Group B and C were experimental groups and were exposed to mosquito coil smoke inhalation for 8 hours/day for two and four weeks respectively. Kidney tissue of albino rats was dissected, examined and analyzed histologically. Results: The results of MCS inhalation in histological sections of group B and C showed marked cellular necrosis and vacuolization in PCT (proximal convoluted tubule) of the kidney as compared to the group A. protein cast was absent in PCT of all groups. DCT (distal convoluted tubules) in group B and C showed marked necrosis, vacuolization and protein cast. Necrosis was more marked in group C treated with mosquito coil smoke for 4 weeks. Conclusion: The results indicate that pyrethroids in mosquito coil smoke though considered least toxic pesticides, are very harmful. Exposure of pyrethroids can induce adverse changes in tubules of kidney. Key Words: MCS Mosquito Coil Smoke, Pyrethroids, PCT Proximal convoluted tubules, DCT Distal convoluted tubules. How to Cite: Siddique N, Ahmed M, Ilyas M, Jabeen R, Jawad A.H, Iqbal Z. histological changes in proximal and distal convoluted tubules of kidney of albino rats after exposure to mosquito coil smoke inhalation. Esculapio.2020;16(04):87-91.