Abstract
The sequence of events in long‐term cultures in lymph node fragments and in underlying three dimensional matrix of gelatin foam (Spongostan) has been studied histologically. Lymphoid cells together with reticulum‐like cells survived excellently in the periphery of the original lymph node fragments until the time of lymphoblastoid transformation 8 weeks after explantation. The centre of the lymph node became increasingly fibroid from the third week onwards. The Spongostan matrix was gradually converted to an organotypic structure where lymphoid cells survived and proliferated. During week 3–6 after explantation only few lymphoid cells were discharged into the medium. At the same time, however, the number of such cells did not decline within the explant. The diminished release could thus not be explained by increased lymphoid cell death at their source of origin, i. e. the original explant. The findings support that lymphoblastoid cells go through a phase of adaptation within the explant.
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Schedule a callMore From: Acta Pathologica Microbiologica Scandinavica Section A Pathology
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