Abstract
Aim:This study aimed to investigate the impact of rabbit serum on skin wound healing with the help of histological examination.Materials and Methods:A total of ten indigenous rabbits were used in this study. The animals were divided into two groups: control and serum- treated. The histological assessment was done with a paraffin embedding technique and the histological sections were stained with H&E stain.Results:Severe infiltration of polymorphonuclear leukocytes with severe fibrin deposits were seen in serum treated group at 2 days post-injury; at 7 days post-injury the changes revealed moderate fibroplasia, fibrin deposit and severe infiltration of both mononuclear and polymorphonuclear leukocytes; at 14 days post-injury, there were marked epithelization and dermal deposition of collagen fibers; and at 21 days post-injury, the epidermis completed epithelization and the dermis showed neither fibroplasia nor infiltration of mononuclear and polymorphonuclear leukocytes.Conclusion:The results indicated that rabbit’s serum can prevent wound infection, accelerate epithelialization and cutaneous regeneration with less granulation.
Highlights
The cutaneous tissue which covers the entire body is composed of keratinized stratified squamous epithelium that represents the epidermis and the dermis, which is composed of interconnected collagen bundles and elastic fibers [1,2]
Aim: This study aimed to investigate the impact of rabbit serum on skin wound healing with the help of histological examination
This study aimed to investigate the impact of the rabbit serum on skin wound healing with the help of histological examination
Summary
The cutaneous tissue which covers the entire body is composed of keratinized stratified squamous epithelium that represents the epidermis and the dermis, which is composed of interconnected collagen bundles and elastic fibers [1,2]. The skin wound is a discontinuity of the soft tissues including cutaneous tissue and the infected wound needs a longer time to repair their associated complications. Skin wounds usually occur by accidental trauma (burns, lacerations, or abrasions), which lead to complications such as delay healing and infection [4]. Serum is a biological body fluid and contains several factors such as growth hormone and insulin-like growth factor [5,6]. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
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