Histological assessment of the effect of neoadjuvant chemotherapy on conventional high grade osteosarcoma of the long bones

Jb Thapa

doi:10.3126/jpn.v1i1.4455

Abstract

A multidisciplinary team of an orthopaedic surgeon, medical oncologist, radiologist and pathologist was involved in the management of osteosarcoma cases. Four cases of osteosarcoma were examined for the effects of neoadjuvant chemotherapy. Total histological mapping was done to study the postchemotherapy biopsies. Two cases were good responders (more than 90% response), and two cases were poor responders (less than 90% response). Good responders had limb sparing surgery performed on them. Long term follow up results are awaited. Keywords: Neoadjuvant chemotherapy; Osteosarcoma; Total histological mapping; Tumour response DOI: 10.3126/jpn.v1i1.4455 Journal of Pathology of Nepal (2011) Vol.1, 60-62

Highlights

Osteosarcoma often presents as a high grade aggressive bony neoplasm affecting mostly the young and sometimes the elderly
Four osteosarcoma cases were referred in the last year from Capital Hospital for pre and post neoadjuvant chemotherapy
A second biopsy was done with wide excision of the bone involved. This was subjected to total histological mapping in the laboratory to study the effect of chemotherapy on the tumour cells as per Huvos et al – Memorial Sloan-Kettering Cancer Center,[1] Salzer-Kuntschik et al – German-AustrianSwiss Cooperative Osteosarcoma Study Group (COSS),[2] Picci et al2 – Instituti Ortopedico Rizzoli (IOR) in Bologna.[3]. In this study the more widely accepted criteria i.e. more 90% necrosis as a good responder and

Summary

Introduction

Osteosarcoma often presents as a high grade aggressive bony neoplasm affecting mostly the young and sometimes the elderly. Four osteosarcoma cases were referred in the last year from Capital Hospital for pre and post neoadjuvant chemotherapy The subjects were biopsy confirmed osteosarcoma patients who were to undergo neoadjuvant chemotherapy at Capital Hospital. Patients were committed to long term care and follow up at that hospital.

Results

Conclusion