Histological and micro-computed tomographic observations after maxillary sinus augmentation with porous hydroxyapatite alloplasts: a clinical case series.

Hidemi Nakata,Emi Okada,Noriko Tachikawa,Maho Akatsuka,Shinji Kuroda,Shohei Kasugai,Hisatomo Kondo

doi:10.1186/s40064-016-1885-2

Hidemi Nakata, Emi Okada + Show 5 more

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https://doi.org/10.1186/s40064-016-1885-2

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Abstract

BackgroundIt is important to visualize the phenomenon which occurs in actual clinical cases to decide the timing of implant placement subsequently after sinus graft. Although several clinical cases of bone augmentation using xenograft have been evaluated, the number of those reports which have described bone remodeling by alloplasty are not sufficient.FindingsIn the present report, to investigate bone remodeling histologically after maxillary sinus augmentation with porous hydroxyapatite alloplast, bone cores from the sinus floor of three female nonsmoking patients (aged 64–73 years) were collected 6 months after sinus lift surgery, embedded in methyl methacrylate resin, and prepared by conventional methods. Bone architecture and graft residues were evaluated by micro-computed tomography of the same specimens. Hematoxylin–eosin and Villanueva–Goldner staining revealed mature osteoblasts and multinucleated osteoclasts on the grafted sinus floor and surface of residual hydroxyapatite particles. The particulate interspace was partially filled with osteoid and calcified tissue and showed active vascularization.ConclusionThe results suggested that bone regeneration and angiogenesis within and between porous hydroxyapatite particles were sufficiently found after 6 month histologically in the grafted sinus floor.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-016-1885-2) contains supplementary material, which is available to authorized users.

Highlights

It is important to visualize the phenomenon which occurs in actual clinical cases to decide the timing of implant placement subsequently after sinus graft
The results suggested that bone regeneration and angiogenesis within and between porous hydroxyapatite particles were sufficiently found after 6 month histologically in the grafted sinus floor
New bone and osteoid were appeared as a blanched area in all Discussion In the present study, bone formation and vascularization were observed 6 months after sinus augmentation with porous hydroxyapatite alloplast. These results confirmed the evidence that 6 month considered as a standard healing period subsequently to sinus grafting would be sufficient for preparation of implant placement (Tatum 1986)

Summary

Introduction

It is important to visualize the phenomenon which occurs in actual clinical cases to decide the timing of implant placement subsequently after sinus graft. Several clinical cases of bone augmentation using xenograft have been evaluated, the number of those reports which have described bone remodeling by alloplasty are not sufficient. Bone conductivity of hydroxyapatite induces bone formation in the particles (Campana et al 2014). Hydroxyapatite particles can be used to Nakata et al SpringerPlus (2016) 5:260 implant surgery and eligible to proceed with it for benefit to patients. Bone cores from the sinus floor of three patients were collected 6 months after maxillary sinus augmentation with porous hydroxyapatite alloplast to investigate bone formation histologically and evaluate bone architecture and graft residues by micro-computed tomography (CT)

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