Abstract
Animal models have been developed in which the role of Helicobacter pylori in the pathogenesis of different gastroduodenal diseases can be investigated. The gnotobiotic pig was one of the first animal models used. In this model, Helicobacter pylori infection causes gastritis, which shows some similarities to that in humans, such as the development of mucosa-associated lymphoid tissue (MALT). Hence, this animal model can be used to study the development of MALT in the normal stomach. The aim of our study is to see if lymphoid tissue is present or absent in the normal stomach of gnotobiotic pigs before birth and if so, to investigate its development and composition as a function of gestational age and location in the stomach. Therefore, we studied 82 foetal piglets using routine histology and immunohistochemistry. Our findings show that lymphoid tissue is present at birth. It is composed of lymphoid nodules, a diffuse mononuclear infiltrate and intra-epithelial lymphocytes. The development is a sequential process. The lymphoid tissue in the stomach at birth is composed of the immunohistochemically different immunocompetent cells normally present. In conclusion, MALT is present in normal foetal gnotobiotic pig gastric mucosa, and in this model the stomach is no exception to the rest of the gastrointestinal tract.
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