Abstract
ABSTRACTBackground: Cerebral amyloid angiopathy (CAA) is a disorder characterized by amyloid deposition in the wall of cerebral blood vessels. The deposits of amyloid occur frequently in the blood vessels of the frontal, parietal and occipital cortex.Objective: To examine the characteristics of CAA classified according to the Vonsattel scale in elderly dogs histologically and immunohistochemically as well as the semi-quantitative evaluation of the amyloid deposits in the different segments of the brain.Animals and methods: The brains of 36 dogs of different breeds and sexes, which had been routinely necropsied, were used and divided into two groups: dogs from 1 to 5 and 10 to 18 years old. The tissue sections were stained by hematoxylin–eosin, Congo red and immunohistochemically.Results: Amyloid was accumulated in the wall of cerebral blood vessels in 70% of dogs over the age of 10 years predominantly in the frontal cortex. CAA was demonstrated in elderly dogs as follows: in the frontal cortex (n = 19 or 63%), the parietal cortex (n = 12 or 40%), the hippocampus (40%) and the cerebellum (n = 5 or 17%). The deposits of amyloid in the wall of blood vessels detected by Congo red staining were also Aβ1-14 and Aβ1-42 immunohistochemically positive. Most commonly, the amyloid deposits affected a moderate number of blood vessels. The accumulation of amyloid was immunohistochemically revealed in the blood vessel walls as well as in the senile plaques and neurons.Conclusion: The amount of amyloid in the arterial walls increased with age in dogs, whereas the amyloid accumulated in plaques was Congo red negative.
Highlights
Amyloidoses are diseases with a heterogenic range and are characterized by interstitial deposition and accumulation of amyloid
We examined the brains of 36 dogs of different breeds and sexes, which had been routinely necropsied at the Department of Veterinary Pathology of the Faculty of Veterinary Medicine, University of Belgrade (Table 1)
No amyloid deposits were found in the brain of dogs from group A
Summary
Amyloidoses are diseases with a heterogenic range and are characterized by interstitial deposition and accumulation of amyloid. The sporadic form occurs much more frequently and mostly as a sporadic condition in the elderly, with an increasing incidence associated with age This form is a very common finding in the brain of patients with Alzheimer’s disease (AD) (Vinters et al 1996; Revesz et al 2002; Kumar-Singh 2008; Mendel et al 2013). Cerebral amyloid angiopathy (CAA) is a disorder characterized by amyloid deposition in the wall of cerebral blood vessels. Results: Amyloid was accumulated in the wall of cerebral blood vessels in 70% of dogs over the age of 10 years predominantly in the frontal cortex. Conclusion: The amount of amyloid in the arterial walls increased with age in dogs, whereas the amyloid accumulated in plaques was Congo red negative
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