Histological and Histomorphometric Evaluation of New Bone Formation after Maxillary Sinus Augmentation with Two Different Osteoconductive Materials: A Randomized, Parallel, Double-Blind Clinical Trial.

Giuseppe Grasso,Adriano Piattelli,Serena Bianchi,Giovanna Iezzi,Enrico Marchetti,Giuseppe D’Ambrosio,Stefano Mummolo,Sara Bernardi,Davide Pietropaoli

doi:10.3390/ma13235520

Giuseppe Grasso, Adriano Piattelli + Show 7 more

Open Access

https://doi.org/10.3390/ma13235520

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Journal: Materials	Publication Date: Dec 3, 2020
Citations: 8	License type: CC BY 4.0

Affiliation: University of Chieti-Pescara, University of L'Aquila

Abstract

This study aimed to investigate the histological features of deproteinized equine bone mineral (DEBM) and anorganic bovine bone (ABB) after human sinus augmentation with the lateral approach. Twenty-three sinus augmentations were performed in 16 patients (male: 10/female: 6) using DEBM or ABB in a randomized fashion. Healing took place over the next 6 months. Bone core biopsies (N = 23) were obtained for each subject prior to placing the dental implants. The biopsies were processed for both histological descriptions and histomorphometric analysis. Statistical analyses were applied as appropriate, defining statistical significance as p < 0.05. Core bone biopsies revealed no differences in terms of newly formed bone between groups, or differences in terms of tissue inflammation. Both DEBM and ABB appear to be suitable biomaterials for bone augmentation in sinus lift surgery in the short term. However, dedicated studies are required to confirm these results and their stability in the long term.

Highlights

The sinus augmentation procedure using the lateral approach is a useful and reliable procedure that allows dental implant placement in edentulous atrophic posterior maxillae when the volume and quality of the bone are insufficient [1]
This concept was further explored by Silva et al in a systematic review published in 2016, which noted that the dental implant survival rate was 96.00% for sinus augmentation performed without grafting and 99.60% for that with bone graft material [7]
This study aimed to evaluate the histological features of deproteinized equine bone mineral (DEBM) and AAB in human sinus lift

Summary

Introduction

The sinus augmentation procedure using the lateral approach is a useful and reliable procedure that allows dental implant placement in edentulous atrophic posterior maxillae when the volume and quality of the bone are insufficient [1]. Various sinus lift techniques have been proposed and sinus floor elevation has been achieved using various surgical procedures [4,5]. According to Chen et al, the presence of biomaterials does not seem to be essential for obtaining the formation of new bone in the maxillary sinus [6]. This concept was further explored by Silva et al in a systematic review published in 2016, which noted that the dental implant survival rate was 96.00% for sinus augmentation performed without grafting and 99.60% for that with bone graft material [7]. Following the regeneration triade principle, which relies on the presence of a scaffold, growth factors, and cellular precursors [8], grafting material plays a key role in the success of the sinus lift procedure [9]

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