Abstract
Samples of 50–100μg of phenol/water-extracted lipopolysaccharides (LPS) from F. nucleatum (strain Fus-MC8) were introduced into 27 sterile root canals in 4 monkeys. Seventeen mechanically devitalized teeth, some of which contained 0.85 per cent saline, were the controls. The experimental periods were 3 or 7 months. The teeth and the surrounding jawbone were examined radiographically, and the root canals assessed for sterility before killing the animals. Enzyme histochemical reactions were observed for diaphorase, acid phosphatase and amino-peptidase activities in serial sections. Inflammatory reactions occurred in the periapical tissues of all the experimental teeth with resorption of both bone and teeth. Even where the inflammatory response was weak, the cells within the apical bone showed increased enzymic activity, suggestive of resorptive activity. The control teeth showed nil or very weak enzyme reactions.
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