Abstract
PurposeDeproteinized bovine bone mineral (DBBM) is a type of bone substitute material widely used in tooth extraction sites. However, there is a lack of evidence supporting the benefit of DBBM used for postextraction socket preservation with regard to new bone formation. This meta-analysis and systematic review was conducted to explore whether site preservation (SP) using DBBM could provide benefits with regard to new bone formation compared with natural healing. Materials and methodsStudies reporting histological results for postextraction SP with DBBM and natural healing from 2000 to 2019 were identified in three databases, and a meta-analysis was conducted. ResultsFive studies were included. The DBBM group had a significantly lower new bone percentage than the natural healing group, with a MD of −24.75 [95%CI: −39.77, −9.73] (P=0.001). The percentage of connective tissue in the extraction site was not significantly different between the two groups, with a MD of 0.60 [95%CI: −4.85, 6.05] (P=0.83). ConclusionsSP using DBBM provided no additional benefit with regard to postextraction new bone formation in comparison with natural healing. Due to the lack of high-quality research, further large-sample studies and standard studies are needed to confirm these conclusions.
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