Histological analysis of rat prostate under exogenous testosterone and low dose of oral selenium administration

Sergio Marcelino De Oliveira,Loiane Dos Santos Silva,Rodolpho Gonçalves Da Silva,Rafaela Heloise Cardoso Ledesma

doi:10.30681/252610103131

Abstract

Objective: to verify selenium effectiveness in maintenance of prostate tissue architecture. Method: experimental study using 20 adult male rats, 90 days old, were divided in followed groups: TG, 05 animals that received testosterone administration; TSG, 05 animals that received testosterone administration and doses of selenium by gavage; CG1, 05 intact animals; CG2, 05 animals that received saline injection, and saline by gavage. Results: characteristic architecture was found in tissue samples from animals of CG with cubic/prismatic secretory epithelium surrounded by fibro-muscular stroma. Animals of TG showed an increase in prostatic epithelium height, increase in the number of blood vessels in stroma and presence of proliferative lesions. Proliferative lesions were also found in tissue samples from animals of TSG, besides having improve in epithelial height, as seen in TG. Conclusion: it is concluded that selenium at this concentration has no effectiveness in modulating morphology of prostatic tissue of adult rats.

Highlights

Prostate gland is the only gland in male reproductive system found in all mammals[1]
Prostate tissue of CG animals were in accordance with those expected for the prostatic epithelium of rodents[23] including basal cells that are responsible for the renewal of epithelial cell populations and high of epithelium
All features found in prostatic compartments of TG prostate demonstrated the action of T in maintaining proliferative and secretory activity of this gland and cell proliferation in prostatic epithelium, that can be responsible for the emergence of various proliferative lesions[7,25]

Summary

Introduction

Prostate gland is the only gland in male reproductive system found in all mammals[1]. In rodents it is divided into three pairs of distinct lobes being called lateral, ventral and dorsal according to their location in relation to urethra. These lobes are connected to urethra by ducts, which are functionally similar to the human prostate[2]. Prostate cancer is the most frequent cancer in men and it is diagnosed in 18% of the males to the end of their lives[3]. Several mechanisms are Journal Health NPEPS. 2018 jul-dez; 3(2):[380-391]

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