Abstract
The ideal approach for the treatment of glottal insufficiency remains a challenge for laryngologists. AimThis experimental study assessed the histological changes and fibrosis caused by autologous fascia lata grafts into the rabbit voice muscle. Study DesignA clinical and experimental study. MethodsA 0.2 × 0.2 cm fragment of autologous fascia lata was grafted into the right voice muscle of 14 adult rabbits. Animals were euthanized 30 or 60 days post-procedure and histology of the excised vocal folds was carried out. ResultsNo extensive edema, necrosis or foreign body-type reaction was observed at any time. No significant inflammatory reaction or fibrosis was seen at 30 or 60 days. ConclusionThe presence of fascia lata in the rabbit voice muscle had no significant influence on inflammation, and does not increase fibrosis. Rabbit voice muscle shows good tolerance to fascia lata grafting.
Highlights
The main functions of the larynx are to protect lower airways and to produce voice
The presence of fascia lata in the rabbit voice muscle had no significant influence on inflammation, and does not increase fibrosis
Paper submitted to the BJORL-SGP (Publishing Management System – Brazilian Journal of Otorhinolaryngology) on June 28, 2009; and accepted on September 15, 2010. cod. 6478
Summary
The main functions of the larynx are to protect lower airways and to produce voice. Glottic insufficiency due to incomplete contact between vocal folds may be caused by several glottal conditions, such as laryngeal palsy, scarring and sulcus vocalis.[1]. Several points should be taken into account when choosing a biomaterial for implantation into the vocal fold. These include: ease of implantation, the type of immune response, and migration of the implanted material to undesired sites.[3]. In 1998, Rihkanen introduced fascia lata for correcting glottic insufficiency.[5] Reijonen et al.[6] injected processed fascia lata into the vocal muscle of dogs in an experimental study, and found that the graft remained histologically identifiable one year later. Rodgers et al.[7] described that processed autologous fascia injected into the vocal muscle was absorbed rapidly after three months
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