Abstract
AbstractFifty‐one synovial biopsies were obtained from the knee joints of 11 patients with rheumatoid arthritis and eight patients with osteoarthritis. Biopsies were taken before and repeated 3–9 days after treatment with phenylbutazone administered orally or intra‐articularly. Histologic comparisons were made with reference to fibrin and fibrinopurulent material, appearance and thickness of synovial lining cells, edema, stromal hyalinization, inflammatory cell type and distribution, vascular alterations and other changes as noted on hematoxylin and eosin and special stained sections.
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