Abstract
This study describes the occurrence of histopathologic characteristics of oral lichenoid mucositis in epithelial dysplasia and squamous cell carcinoma. This retrospective review examined 352 histologic specimens of group 1 (mild to moderate dysplasia), group 2 (severe dysplasia or carcinoma in situ), and group 3 (squamous cell carcinoma) for correlation between 5 histologic characteristics frequently found in oral lichen planus and grade, age, gender, and oral subsite. In this sample, 29% of all cases exhibited 3 or more lichenoid features. Lichenoid features were significantly more frequent in group 1 over group 2 lesions for cases meeting a minimum lichenoid threshold (P = .001). No statistically significant patterns were noted for age or gender. The buccal mucosa was significantly overrepresented (P = .039) and the floor of the mouth was significantly underrepresented (P = .049) in regard to lichenoid feature frequency. This study confirms the frequent correlation of lichenoid characteristics in oral premalignant and malignant lesions.
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