Abstract
The pineal glands of the golden hamster and rhesus monkey were examined with FalckHillarp histofluorescence and electron microscopic techniques. Serotonin fluorescence, distinguished by microspectrofluorophotometry, was observed in virtually all pinealocytes in the rhesus monkey, but was demonstrable in only a small percentage of such cells in the hamster. Ultrastructurally, dense core vesicles, commonly proposed as sites of monoamine storage, were seen in most pinealocytes in hamster, but were rarely observed in pinealocytes of the monkey. Perivascular catecholamine fluorescence was present in both monkey and hamster, but to a greater extent in the latter. These data may provide a useful model for the correlation of fluorescence demonstrable indoleamines with the occurrence of dense core vesicles.
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