Abstract
Histochemical investigations have been made on cryostat sections of mouse cervix implanted with either a beeswax-impregnated thread (control) or a 20-methylcholanthrene-impregnated thread in one of the cervical canals. New squamous epithelium (epidermization) and squamous carcinomas were observed in approximately 100% and 50% of the cases respectively, after 4–6 weeks. The 6-week animals showed more advanced tumours compared with the animals killed after 4 weeks. The glycogen staining of the cervical canals treated with beeswax- or methylcholanthrene-impregnated thread was greatly enhanced compared with the untreated control cervical canal. The activity of glycogen synthetase, phosphorylase and lactic dehydrogenase was enhanced in the treated part of the cervix. On the other hand, the activity of acid phosphatase and simple esterase was diminished in the cervical canal treated with beeswax- or methylcholanthrene-impregnated thread. Some other enzymes did not show any changes. Alkaline phosphatase preparations, however, showed significant reduction in the enzyme activity in the carcinogen-treated cervical canal compared with either the untreated or the beeswax-treated canal, an effect which could be specifically attributed to the effect of the carcinogen.
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