Abstract
Two sulfated compounds of epithelial origin were identified in the dog gastric mucosa by histochemical and autoradiographic (35SO4) technics. One is a sulfated glycoprotein produced by the surface epithelium and the other a chondroitin sulfate A- or C-like material occurring in chief cells and pyloric glands; both glycoprotein and acid mucopolysaccharide probably contribute to the sulfated fractions found chemically in dog gastric juice. A sialidase-susceptible mucin was found predominantly within superficial cells of the fundus and autrum, and this may be the source of the sialic acid found in the secretions. A strictly neutral glycoprotein was found in the mucous neck and parietal cells, perhaps indicating a relationship between these two cellular elements. In cells containing neutral and acidic mucins, the vicinal hydroxyl and anionic groups were judged to be in close proximity. Strong staining for basic protein was found in parietal cells and a less intense reaction in surface epithelium. Sulfur-containing amino acids were identified by direct and indirect technics in the surface epithelium.
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