Histochemical, Immunohistochemical and Cytogenetic Markers in Salivary Gland Tumor Pathology

Abstract

Evaluation of: Adeyemi BF, Kolude BM, Akang EE, Lawoyin JO: A study of silver nucleolar organizer regions in categorization and prognosis of salivary gland tumors. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 102, 513-520 (2006). In this study, various confirmed benign and malignant salivary gland tumors underwent a known histochemical silver staining method involving nuclear-associated proteins with diagnostic and prognostic capacity in other malignant tumors. The study examined the methods' ability to differentiate between benign and malignant salivary gland tumors and between different histopathological grades of malignant tumors, and sought correlations between the staining results and staging, metastatic disease and survival. The staining method proved inadequate, confirming many previously published results. This article highlights the growing awareness of pathologists and oral pathologists in developing countries to the uniqueness of salivary gland tumors, and demonstrates their understanding of the importance of both early detection and appropriate treatment.