Abstract
Objective. Study was designed to reveal the prognostic significance of Ki-67, IgA and mucin secretion in ovarian neoplasms. Methods. Samples of ovarian tumours of 42 female patients were routinely processed and stained with anti-Ki67 and anti- IgA antibodies as well as with histochemistry methods for mucin verification. Results. In our study proliferation marker Ki-67 was proven to be a good prognostic tool of the degree of the cellular atypia. High immunoglobulin A expression was verified in the epithelium and along the luminal border of well differentiated tumors. Histochemical mucin analysis showed quantitative and qualitative changes in mucin secretion that correlates with the degree of tumor differentiation. Conclusion. Ki-67, IgA and epithelial mucins are valid prognostic factors in ovarian neoplasms.
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