Abstract
Summary and ConclusionsMercuhydrin, when administered to rats by subcutaneous injection causes a marked depression of succinic dehydrogenase activity in the proximal convoluted portion of the kidney tubules, while other portions of the nephron are little affected. This enzymatic inhibition is concomitant with the known time of diuresis and both can be prevented by the administration of BAL. This suggests that the enzymatic inhibition is, in fact, related to the diuresis. This places the locus of mercurial action on the proximal convoluted tubule-most certainly as regards its inhibition of succinic dehydrogenase activity and by implication also its diuretic action
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