Histochemical and histo-autoradiographical changes in gastric mucosa of dogs submitted to chronic cortisone administration.

Abstract

The effects of chronic cortisone administration on the synthesis and excretion of sulfated mucosubstances by the gastric mucosal cells were studied in dogs by the means of histochemical and autoradiographicprocedures. During the treatment, radiosulfate uptake was obviously increased in the crypt cells and the chief cells of the fundic area and in some pyloric glands of the antrum, while extracellular sulfated mucosubstances appeared in the lumen of the glands. In a few areas of the antrai surface and, constantly, around the observed ulcerous lesions, intra- and extracellular mucus content, and labelling was, on the contrary, reduced.