Abstract
Rotaviruses (RVs) are one of the most important pathogens for the viral gastroenteritis in human and animals. It is reported that histo-blood group antigens (HBGAs) may be the receptors and/or attachment factors for the RVs. HBGAs are highly polymorphic including ABO, secretor, and Lewis antigens. According to the previous studies, RVs of different P genotypes have been shown to interact with HBGAs in the genotype-dependent manner and there is various RVs susceptibility between different people. Therefore, the research of the interaction between RVs and HBGAs is significant to clarify the mechanism of RV pathogenesis and lays the foundation for the RV vaccine design.
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