Abstract
Introduction: Histiocytosis is a disease caused by growth of histiocytes within one or more organs. Symptomatology may be very different: from isolated skin or bone lesions, by diabetes insipidus after life-threatening multisystem form. Diabetes insipidus as a symptom of pituitary can be observed many years before visibility of the changes in magnetic resonance imaging. Case report: A case of 59 -year-old woman who has experienced diabetes insipidus with no other symptoms of hypopituitarism is presented in this study. It was the only symptom of the disease. She felt very well and she didn’t receive any medical treatment. Increased level of OB, LDH, and decreased urine specific gravity were found in the laboratory tests. MRI of the pituitary revealed infiltration of the hypothalamic pituitary area. Extensive diagnostics was conducted to be sure that inflammatory didn’t cause the infiltration. During this process, the presence of numerous, multiorgan changes (numerous small focal lesions in the lung, gallbladder, ovaries) was revealed. Because of polyuria she received desmopressin.
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