Abstract
The collective term histiocytoid hemangioma encompasses a spectrum of diseases that share a histologic features characterized by distinctive histiocytoid endothelial cells. Several incompletely defined cutaneous and extracutaneous vascular tumors, including atypical pyogenic granuloma, pseudopyogenic granuloma, papular angioplasia, angiolym-phoid hyperplasia with eosinophilia, Kimura’s disease, and inflammatory arteriovenous hemangioma, have been included in this group. We describe a 31-year-old Mexican-American man with multiple histiocytoid hemangiomas involving skin, subcutaneous tissue, and bone limited to the left arm and hand. Examination of skin and bone lesion biopsy specimens showed a proliferation of histiocytoid endothelial cells with intracyto-plasmic vacuoles and associated vascular lumen formation. Ultrastructural and immuno-peroxidase studies supported endothelial cell differentiation. Radiation therapy resulted in significant clinical improvement. Current concepts regarding the clinical and pathologic features of this disease spectrum also are discussed.
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