Abstract
An autopsy case of histiocytic medullary reticulosis (HMR) in a 55‐year‐old man is presented. The initial complaint of the patient was an unusual skin lesion on the right upper arm, and subsequently developed generalized erythematous skin lesions which regressed during the course of the illness. The clinical symptoms and course of the disease were those of HMR. The affected organs were lymph nodes, spleen, liver and bone marrow as well as the skin, in which erythrophagocytic histiocytes predominated in abnormal cells of the histiocytic series. Phagocytic histiocytes had large amounts of cholesterol and small amounts of phospholipids which might be originated from the ingested erythrocytes. The electron microscopy suggested the presence of phospholipid‐cholesterol interaction in the phagocytic histiocytes.
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