Abstract
Adenosine 5'-triphosphate (ATP) induced a non-cytotoxic, calcium-dependent release of histamine and prostaglandin D2 from rat serosal mast cells. The effect was tissue and species specific. In particular, tissue mast cells from the guinea pig and man were totally unresponsive. The release evoked by the nucleotide was unaffected by antiasthmatic chromones but was inhibited by structurally related flavonoids and by cAMP-active drugs. Secretion was blocked both by the P2Y-purinoceptor antagonist reactive blue 2 and the P2X-antagonist suramin, whereas the P2-agonists 2-methylthio ATP, alpha, beta- and beta, gamma-methylene ATP were inactive. These findings indicate that ATP acts through a novel purinoceptor or binding site which is present on certain types of mast cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
