Abstract
Four ragweed-sensitive patients were treated by courses of injections of aqueous ragweed extract. Specific histamine release from peripheral leukocytes and circulating antibody to purified ragweed antigen were measured at various times. During treatment, a progressive increase was observed in the concentration of antigen required to release a significant proportion of the total cellular histamine. No marked changes occurred in any patient before a total of at least 20, 000 PNU of ragweed extract had been administered. The level of circulating antibody rose during therapy. Changes in serum antibody preceded changes in sensitivity of the leukocytes. After treatment a decrease in symptoms during the next ragweed season was reported by each of the patients.
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