Abstract
The effects of defibrotide (DFT) and its fraction P.O. 085 D V on rat serosal mast cell histamine release evoked by free radicals were studied. Free radical production was obtained with: a) metabolic activation of arachidonic acid and cocaine by means of liver microsomes (S-10 mix) from polychlorinated biphenyl mixture (PCB)-treated rats; b) metabolic activation of arachidonic acid by means of prostaglandin-H-synthetase (PHS) and c) human platelet aggregation induced by arachidonic acid. DFT and its fraction reduced histamine release evoked by aggregating human platelets; P.O. 085 D V significantly reduced histamine release evoked by metabolic activation of both cocaine and arachidonic acid in the presence of S-10 mix, while DFT was less active on the cocaine-S 10 mix system and ineffective on the arachidonic acid-S 10 mix system. Both drugs were unable to decrease histamine release induced by metabolic activation of arachidonic acid in the presence of PHS.
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