Abstract
Histamine is a highly pleiotropic biogenic amine involved in key physiological processes including neurotransmission, immune response, nutrition, and cell growth and differentiation. Its effects, sometimes contradictory, are mediated by at least four different G-protein coupled receptors, which expression and signalling pathways are tissue-specific. Histamine metabolism conforms a very complex network that connect many metabolic processes important for homeostasis, including nitrogen and energy metabolism. This review brings together and analyses the current information on the relationships of the “histamine system” with other important metabolic modules in human physiology, aiming to bridge current information gaps. In this regard, the molecular characterization of the role of histamine in the modulation of angiogenesis-mediated processes, such as cancer, makes a promising research field for future biomedical advances.
Highlights
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, To Professor Rafael Peñafiel, in memoriam
The role of histamine in angiogenesis, was first suggested in 1983 when Fraser and Simpson showed that histamine produced by mast cells induces neovascularization in a chorioallantoic membrane model; this induction was not replicated by Barnhill and Ryan who reported negative results with histamine 0.1 mM [103,104]
Network [122], and OmniPath [123]; from which we modelled the network of signalling interactions between the histamine receptors and the genes involved in reprogramming cancer metabolism, so we obtained a general view of how histamine participates in reprogramming tumour metabolism
Summary
Histamine (2-(1H-Imidazol-4-yl) ethanamine) is the product of the alpha decarboxylation of the essential amino acid histidine (2-Amino-3-(1H-imidazol-4-yl) propanoic acid) by the enzyme histidine decarboxylase (HDC). Antagonistic time courses of histamine and PA metabolisms have been observed in several pathophysiological scenarios such as in murine mast cells differentiation and basophilic leukemia cells [11,12,13,14] This evidence has been recently reviewed in the context of different pathophysiological scenarios [15,16]. The physiological effects of histamine are dependent on the receptor expressed by each cell type in each physiological context, oftentimes inducing opposite effects on different cell types or cellular status. These facts add further complexity to the analysis and discussion of experimental results.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
