Abstract
Histamine was measured in the plasma, liver, and thymus of male rats fed a magnesium-deficient diet for 65 days. Histological study of the thymus was also performed. Histamine levels in plasma and tissue increased rapidly and reached a maximum after 10 days of deficiency. Later on, the level of histamine in deficient animals decreased and fluctuated but was usually higher than in the controls. One rat killed after 60 days of deficiency showed a very large thymus, weighing 1.8 g, which extended into the thoracic cavity. Histological study revealed a complete replacement of the normal thymic cells by large basophilic lymphocytes invading the neighboring organs including the heart muscle. The tumor was transplanted successfully in normal rats receiving a well-balanced diet. Another smaller tumor was found in an animal killed at 65 days. Thymuses of control animals were all normal. The development of tumors of the thymus in magnesium-deficient rats is discussed in connection with the changes in tissue histamine.
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