Abstract
Total histamine levels in heart, lung, stomach and skeletal muscle are not significantly different between normotensive (NT) and desoxycorticosterone acetate (DOCA) — hypertensive (HT) rats. Histamine depletion from skeletal muscle and heart of NT and HT rats by Compound 48/80 was similar indicating that the mast-cell pool(s) of histamine are of equivalent size. Tissue levels of 3H-histamine following 3H-histidine administration of NT and HT rats indicated that the capacity for histamine formation is unaffected by the hypertensive state. This conclusion was reinforced by the finding that histamine turnover rates were similar in tissues from NT and HT rats. Studies of 3H-histamine metabolism suggest that an alteration in histamine methylation capacity may exist in the hypertensive rat. The relationship of altered histamine disposition to the reduced magnitude of histaminergic reflex vasodilatation noted in the hypertensive rat is discussed.
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