Abstract
Enzymatically dispersed rat gastric cells were subdivided (Percoll) in fractions (F1, F2, F3) with different number of parietal cells (PC) and the intracellular histamine content was estimated (ng/10(6) cells): F1 (9% PC): 17 +/- 4 (SEM), F2 (26% PC): 80 +/- 9 and F3 (77% PC): 134 +/- 15. Histidinedecarboxylase showed the same pattern of distribution, F1 low, F2 medium, F3 high activity. Incubated F3 cells constantly released histamine (19 +/- 3 ng/10(6) cells/h), a process which could be stimulated by carbachol, forskolin and hexoprenaline. The data suggest: rat gastric histaminocytes copurify with PC, background stimulation by histamine should be considered in isolated cell systems, vagal stimulation may release histamine within the gastric mucosa.
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